Abstract: Posterior capsule opacification (PCO) is the most common complication after cataract surgery. PCO is formed by the proliferation, migration, epithelial-mesenchymal transition, and wound healing reaction of the residual lens epithelial cells after cataract surgery. Modification of the intraocular lens (IOL) to prevent and treat PCO has the advantages of excellent targeting efficiency and fewer follow-up medical intervention. According to the effect materials of IOL modification, it can be classified into two types: drug loading and non-drug modification. According to whether the effect of preventing or inhibiting PCO can be controlled, it can be classified into the controllable modification and non-controllable modification. (Int Rev Ophthalmol, 2022, 46: 22-28)

Key words: intraocular lens, posterior capsule opacification, lens epithelial cell, epithelial-mesenchymal transition